Neither agonists nor antagonists of CB1 or GPR40 receptors were found to modulate insulin signalling as determined by phosphorylation of downstream targets Akt and GSK3alpha/beta.Global expression profiling was also carried out on myotubes treated with GPR40 agonists and antagonists obtained from AstraZeneca. No changes in metabolic or insulin signalling genes were observed. Rather, antagonists of GPR40 appear to activate gene expression networks involved in cell proliferation in particular an elevation in the ERBB2 signalling pathway..
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